ABSTRACT
Crude chloroform extract of C. papaya seeds (5 mg/animal/day, po, for 20, 40 and 60 days) was investigated for contraceptive efficacy and related side effects in male albino rats. The crude extract reduced fertility to zero per cent by 40 to 60 days of treatment. Suppression of cauda epididymal sperm motility was the most pronounced effect of the drug administration. Scanning electron microscopic observations revealed treatment induced abnormalities in sperms. Cauda epididymal and testicular sperm counts decreased following treatment. Clinical parameters did not show any alterations. Results suggest that the contraceptive effects of chloroform extract of papaya seeds are mainly post-testicular in nature without influencing toxicological profile and libido of the animals.
Subject(s)
Animals , Contraceptive Agents, Male/isolation & purification , Erythrocyte Count/drug effects , Fertility/drug effects , Leukocyte Count/drug effects , Male , Plant Extracts/pharmacology , Rats , Rats, Sprague-Dawley , Seeds , Sperm Motility/drug effectsABSTRACT
The effect of Amiodarone (AD), a cationic amphiphilic drug, on erythrocytes and leucocytes was studied. Treatment of rats with AD showed a significant decrease in the red cell count and the level of Hemoglobin. Amiodarone altered the fluidity of the erythrocyte membrane followed by a decrease in the activities of membrane bound enzymes like (Na+, K+)-ATPase, Acetylcholine esterase and NADH dehydrogenase. A slight increase in the leucocyte count was also observed in the treated animals.
Subject(s)
Amiodarone/pharmacology , Animals , Cholesterol/metabolism , Erythrocyte Count/drug effects , Erythrocyte Membrane/drug effects , Hemoglobins/metabolism , Leukocyte Count/drug effects , Male , Membrane Fluidity/drug effects , Phospholipids/metabolism , Rats , Rats, Wistar , Sodium-Potassium-Exchanging ATPase/bloodABSTRACT
Investigations into the haemolytic effects of dapsone therapy were carried out in forty four leprosy patients admitted to the Sacred Heart Leprosy Centre, Kumbakonam. They received weight based dapsone dosages varying from 1.3-3.3 mg/kg body weight. Blood levels and urinary Dapsone/creatinine ratio were assessed at 1 day, 7 days and 30 days of Dapsone treatment. At the same points of time, haematological observations were also carried out. Serum bilirubin as well as blood mathaemoglobin were also examined. The findings showed a reduction in Hb levels at 30 days observation in a good proportion of cases on 100 mg. In one case (child) weighing 15 kg and receiving 50 mg dapsone increased mathaemoglobin was observed. It is suggested that dapsone dosage be regulated to body weight and preferably not to exceed 1.5 mg/kg body weight.
Subject(s)
Adolescent , Adult , Bilirubin/blood , Body Weight , Child , Dapsone/administration & dosage , Drug Administration Schedule , Erythrocyte Count/drug effects , Female , Hemolysis/drug effects , Humans , Leprosy, Borderline/drug therapy , Leprosy, Lepromatous/drug therapy , Leprosy, Tuberculoid/drug therapy , MaleABSTRACT
O sulfato de gentamicina é um dos antibióticos aminoglicosídeos mais utilizados em antibioticoterapia. Ele produz efeitos colaterais como nefrotoxicidade, que requer muito cuidado no seu uso, e achamos relevante analisar as possíveis alteraçöes na série vermelha em doses terapêuticas e doses elevadas, estas compatíveis com lesäo renal. Para isto utilizou-se 173 ratos divididos em grupos, que receberam água destilada, e 5 mg/kg, 10 mg/kg, 20 mg/kg e 40 mg/kg de Gentamicina durante 5, 10, 15 e 20 dias respectivamente. Foram retiradas amostras sanguíneas, de todos os animais efetuado eritrograma. Observou-se que ocorreu diminuiçäo dos eritrócitos com doses de 20 mg/kg e 40 mg/kg aos 5 e 10 dias, e que estas foram reversíveis